A single antibody induces tumors from seven different human beings. lipo twin cancer implanted into rats to shrink. down or gone, according to a new study led by Stanford University School of Medicine in the United States. Researchers hope to replicate this remarkable discovery with human testing within the next two years.
Senior author Dr. Irving Weissman, professor of pathology at Stanford, and colleagues wrote about their success in treating bladder, brain, breast, colon, liver, ovarian and prostate cancer tumors this week. Online ahead of the printing problem of the implementation of National Institute of Scientific Research
They say it blocks antibodies to a protein called CD47 that transmits 'don't eat me'. A signal that cancer cells use to stop macrophages and other cells of the body's immune system from swallowing them up.
Anti-CD47 is the first antibody treatment to work on a variety of human solid tumors. Researchers say they are now keen to begin with Phase 1 and Phase 2 human clinical trials within two. next year
The treatment also significantly reduced the tumor's ability to spread. (metastasize) to other parts of the body of rats and in some cases the animal appears to “lost”
Weissman, who leads the Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center for Stem Cell Research and Medicine, both at Stanford, told News their findings show. “end” Where CD47 is a 'right and promising target for humans' Cancer Treatment “:
“This blog doesn't eat me 'Growth inhibitory signal in rats for almost all human cancers we tested with minimal toxicity' Weissman said:
Dr. Robert Weinberg is a professor of biology at the Whitehead Institute for Medical Research in Massachusetts and was not involved in the research. “Exciting work” that is bound to cause a global rush to translate these findings into useful treatments.
'Mobilizing the immune system to attack solid tumors has been a long-standing goal of many cancer researchers for decades.' Weinberg said
The Weissman lab has discovered that CD47 is normally expressed on the surface of the circulating blood stem cells as a way to stop them being attacked by macrophages, the clean-up cells of the immune system that go around. to find a rogue cell to get rid of But sometimes get it wrong
The CD47 signal informs the macrophage to release stuck cells.
Weissman and colleagues have also previously discovered that certain cancer cell types such as leukemia and lymphoma have also found a way to express CD47 on the surface of leukemia. them to send “don't eat me” signs and avoid being eaten by macrophages.
They found that by giving mice with non-Hodgkin's lymphoma, antibodies that block CD47 in combination with agents that enhance macrophages. ‘Kill some of their healing instincts
But what they didn't know then this strategy was also being used by many other human cancers, and thus this important medical method could be a potential cure.
This latest study involves experts from many fields including oncology, urology, obstetrics and gynecology, radiation oncology, surgery, hematology, pathology, otolaryngology and liver.
The researchers found that almost every human cancer cell they examined, CD47 expressed, on average, about three times the most non-cancerous cells.
It was also found that people with more cancer cells expressing CD47 were less likely to live as long as those with similar cancers. but few cancer cells express CD47. This feature will be a very useful tool in cancer prognosis.
When they obtained human tumor samples, the researchers implanted them in paired rat body parts prepared for tumors, such as breast milk fat pads, and ovarian tumors into the abdomen.
Two weeks later, when the tumors had improved, they began treating the mice with CD47-blocking antibodies.
The researchers noted that within a week most of the tumors began to shrink and in some cases even disappeared.
In five cases, mice transplanted cells from the same person's breast cancer tumor. When the tumor disappeared, the researchers stopped the treatment.
The rats were still cancer-free four months later.
The researchers concluded:
“The results of this study show that antibodies against CD47- can significantly inhibit the growth of human solid tumors by Blocking the ability to transmit CD47 ‘don't eat me’ lipo twin macrophages signal.”
Weissman said that if the tumor was highly aggressive, the CD47 antibody was also blocked from spreading.
“It is very clear that in order for the cancer to survive in the body it has to find some way to evade the body's innate immune system cells. he explained
The innate immune system is the first line of defense against invading pathogens such as viruses and bacteria. Its response is more general that the adaptive response of the body's immune system with adaptive antibodies and T cells can be at It recognizes and attacks specific molecules.
However, in some cases, CD47 antibody treatment did not work. A group of mice grown with human breast cancer cells from one specific patient showed no response.
Weissman said there is still a lot to learn.
'We need to learn more about the relationship between macrophages and tumor cells and how to draw more macrophages in tumors.' he explained
Perhaps shrinking the tumor with surgery or radiation therapy before the antibody treatment will help, or even be used with another antibody to stimulate the body's immune cells to kill cancer cells, he said.
Meanwhile, the researchers believe their findings are enough to show this single antibody holds promise and sets the stage for advance research.
Weissman says they want to move forward Lipotwin. Thousands ” quickly But cautiously, only 1.2% of Americans met all seven cardiovascular health indicators 2005-2010 versus 2% 1988-1994, researchers reported this week in JAMA. (Journal of the American Medical Association) Although some factors have improved, such as smoking rates, others have not been described.
The study, said the nationally representative demographic sample, found that among nearly 44,959 adults who met at least seven of the American Cardiovascular Association's recommended healthy behaviors, the risk of death was substantially lower compared to that. Those who experience less behavior
The authors say a very small percentage of US adults routinely respond to all seven factors.
It's the basics that the researchers write:
“Cardiovascular disease (CVD) is the leading cause of death in the United States [more than 800,000 or about 1 in 3 overall deaths/year] with an estimated direct and total annual cost of $273 billion; and $444 billion respectively”
The AHA (American Heart Association) recently announced seven recommendations for improving heart/cardiovascular health, which will result in fewer cardiovascular-related deaths.
Recommended behavior (cardiovascular health indicators) include:
- Non-smoker
- Exercise (Usage)
- Have blood pressure under control.
- Maintaining healthy blood sugar levels.
- Maintaining blood health cholesterol level
- health care of body weight
- Following a healthy and balanced diet
Quanhe Yang, Ph.D., from the CDC (Centers for Disease Control and Prevention), and a team set out to examine what trends these health indicators are in the United States and how they might affect. all cause and cvd The mortality rate is based on data from NHANES (National Health and Nutrition Examination Survey), which includes 44,959 people aged 20+ during which many have been monitored since 1988. until late 2006
Below is some information from their findings (1988-2006):
- The smoking rate has continued to decline.
- Blood pressure has not improved.
- Cholesterol levels in the blood have not improved.
- Number of people who achieved a satisfactory body mass index. (Body Mass Index) has decreased.
- Fewer people have achieved desirable levels of glucose.
- 2% of people who met all 7 cardiovascular health indicators in 1988-1994 compared to 1.2% in 2005-2010.
The following group of people were found to have found a large number of cardiovascular health indicators: individuals with higher academic levels, non-Hispanic Caucasian women and younger adults of both sexes.
The author writes:
“In the middle [Midpoint] 14.5 years of follow-up in the NH. ANES III cohort-linked participants file that met 6 or more versus 1 or fewer cardiovascular health indicators lipo twin. Review 51% reduced risk of all-cause mortality. There is a lower risk of 76 percent of CVD deaths and a lower risk of 70 percent of IHD deaths. It is linked to a lower risk of dying for all cancers. “
According to their analysis, younger participants had a much lower long-term risk of preterm CVD death if they met all cardiovascular health indicators.
The researchers added
In conclusion, our findings show that the presence of a large number of cardiovascular health indicators is associated with a slow and significantly reduced risk of total mortality. and CVD
Healthy People 2020 and the AHA National Strategy to reduce CVD morbidity and mortality by 20 percent by 2020 through promoting appropriate cardiovascular health indicators is a great challenge. but still achievable
Coordinating efforts such as the recently announced Million Hearts Initiative organizes CVD prevention and control activities in the public and private sectors to create opportunities to reduce the burden of CVD across a large portion of the population. “
editor in the same journal
Donald M. Lloyd-Jones, MD, Sc.M., of the University of Feinberg School of Medicine, Chicago, wrote in an accompanying editorial in the same issue of JAMA:
Despite the apparent difficulty in achieving that goal, there is much to be optimistic about and many opportunities for physicians, policymakers and consumers to support improvements in cardiovascular health. blood
The ongoing focus through the health care system on meeting primary and secondary prevention goals is crucial so that at-risk individuals can take one step forward from the unhealthy to central cardiovascular
Lipotin The counterfeit will gain the necessary support for new public health and social policies to tilt the playing field towards healthy electives, more individuals can move from the middle level. reach ideal levels or maintain ideal cardiovascular health
The debate over this year's farm bill, which will set policies for the coming year, represents an opportunity to support cardiovascular health and a healthy food supply for all efforts to reduce sodium in the United States. Continuous food supply in many areas. “
lipo twin pantip : http://www.lipotwin.in.th/